Cell Growth and Death

Regulation of the Cell Cycle

Cell growth and division are tightly regulated processes that ensure normal development, tissue repair, and maintenance of homeostasis. The cell cycle describes the sequence of events through which a cell replicates its DNA and divides into two daughter cells. Understanding the phases of the cell cycle and their regulatory checkpoints is essential for recognising how uncontrolled proliferation leads to disease.

DNA Replication and Mitosis

Accurate DNA replication is fundamental to cell survival. This section explores the mechanisms of DNA replication, the structure of chromosomes, and the stages of mitosis that allow for equal distribution of genetic material. These processes are central to growth, tissue regeneration, and the maintenance of genomic stability.

Meiosis and Programmed Cell Death

In addition to mitosis, this section covers meiosis, the specialised form of cell division that produces gametes and generates genetic variation. The physiology of cell death is equally important, as controlled mechanisms such as apoptosis prevent the accumulation of damaged or abnormal cells. Together, these topics provide a foundation for understanding oncology, genetics, and developmental biology in clinical medicine.

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DNA Replication

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Apoptosis

Microscope image showing purple-stained cells in various stages of mitosis, with a 10 μm scale bar.

Mitosis

The Cell Cycle

Diagram showing the stages of meiosis II—prophase II, metaphase II, anaphase II, and telophase II—leading from two daughter cells to four daughter cells.

Meiosis

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Diagram of the HPA axis showing stress and diurnal regulation influencing the hypothalamus, which releases CRH to stimulate the anterior pituitary to release ACTH. ACTH stimulates the adrenal cortex to produce cortisol, which affects multiple target organs and provides feedback inhibition.
Anterior Pituitary Gland

Cortisol and the HPA Axis

by Kishan Pankhania and Elly Voogt

Diagram of a platelet cross-section labeled with microtubules, dense tubules, surface-connected tubules, coat, glycogen, mitochondria, alpha granules, and dense granules.
Haematology

Platelets

by Tanzeelah Jamadar

Bones

Bone Ossification

by Rosamund Nicholson