Gas exchange is the process by which oxygen and carbon dioxide move between the bloodstream and the lungs. This is the primary function of the respiratory system and is essential for ensuring a constant supply of oxygen to tissues.
This article will discuss the principles of gas exchange, factors affecting the rate of exchange, and relevant clinical conditions.
Physics of Gas Diffusion
The movement of gases in a container (in this case, the lungs) is random, but overall diffusion results in movement from areas of high concentration to those of low concentration. This happens because gases will expand to fill the available volume.
Collision of the molecules of gas with the sides of the container results in pressure, defined by the equation below, in which n represents the number of moles, R the gas constant (8.314), T the temperature and V the volume of the container.
Diffusion of Gases Through Gases
When gases are diffusing through other gases, as in the alveoli, their rate of diffusion can be defined by Graham’s Law:
“The rate of diffusion is inversely proportional to the square root of its molar mass at identical pressure and temperature”
In other words, the lighter a gas is, the more rapidly it will diffuse. In this situation oxygen, being smaller than carbon dioxide, would diffuse faster.
Diffusion of Gases Through Liquids
When gases are diffusing through liquids, for example across the alveolar membrane and into capillary blood, the solubility of the gases is important. The more soluble a gas is, the faster it will diffuse.
In this case carbon dioxide diffuses much faster than oxygen, as it is much more soluble.
Fick’s law gives us a number of factors that affect the diffusion rate of a gas through fluid:
- The pressure difference across the diffusion barrier
- The solubility of the gas
- The cross-sectional area of the fluid
- The distance molecules need to diffuse
- The molecular weight of the gas
- The temperature of the fluid – not important within the lungs and can be assumed to be 37oC
In the lungs, whilst oxygen is smaller than carbon dioxide the difference in solubility means that carbon dioxide diffuses roughly 20 times faster than oxygen. Normally this is compensated by the large difference in partial pressures of oxygen, however, it does mean that in disease oxygen exchange is often compromised before that of carbon dioxide.
Diffusion of Oxygen
The partial pressure of oxygen is low in the alveoli compared to the external environment. This is due to continuous diffusion of oxygen across the alveolar membrane and the diluting effect of carbon dioxide entering the alveoli to leave the body.
Despite this the partial pressure is still higher in the alveoli than the capillaries, resulting in a net diffusion into the blood. Once it has diffused across the membrane it combines with haemoglobin to form oxyhaemoglobin for transport.
Further information on the transport of oxygen within the blood can be found here.
During exercise blood spends around half the normal time in the pulmonary capillaries due to the increase in cardiac output. However diffusion of oxygen is complete within 0.5s of the blood cell arriving in the capillary, but at rest blood cells spend around 1s in capillaries. This means that exercise is not limited by gas exchange.
Diffusion of Carbon Dioxide
The partial pressure of carbon dioxide in the capillaries is much higher than that in the alveoli. This means that net diffusion occurs into the alveoli from capillaries. The carbon dioxide can then be exhaled as the partial pressure in the alveoli is also higher than the partial pressure in the external environment. However it is important to note that these pressure differences are much smaller than those for oxygen, as carbon dioxide is able to diffuse more rapidly.
Carbon dioxide is transported in the blood in multiple ways; including dissolved, associated with proteins and as bicarbonate ions. Further information on transport of carbon dioxide in the blood can be found here.
The diffusion barrier in the lungs is roughly 0.6 µm and consists of the following layers:
- Alveolar epithelium
- Tissue fluid
- Capillary endothelium
- Red cell membrane
Factors That May Affect The Rate of Diffusion
- Thickness of the Membrane – Whilst the diffusion barrier is normally only 0.6 µm within the lungs some diseases can cause this to increase. For example, fluid in the interstitial space or thickening of the alveolar membrane through fibrotic disease. Any increase in the thickness will impair normal gas exchange.
- Surface Area of the Membrane – Normally the lungs have a very large surface area for gas exchange through multiple alveoli. However diseases such as emphysema lead to destruction of these and can reduce the surface area available – slowing the rate of gas exchange.
- Diffusion Coefficient of the Gas
- Pressure Difference Across the Membrane
Clinical Relevance – Emphysema
Emphysema is a chronic, progressive disease that results in destruction of the alveoli in the lungs. This results in a greatly reduced surface area for gas exchange in the lungs, which typically leads to hypoxia (Type 1 respiratory failure).
The main symptom is shortness of breath, however patients may also experience wheezing, a persistent cough or chest tightness. The main cause is smoking, and emphysema, alongside chronic bronchitis are the conditions that make up Chronic Obstructive Pulmonary Disease (COPD). Whilst smoking is the most common cause, other risk factors include exposure to secondhand smoke, exposure to fumes/dust at work and living in areas with high levels of pollution.
Treatment depends on the stage of the condtion (i.e. the degree of symptoms and airway obstruction) but typically includes:
- Stopping smoking
- Inhaled corticosteroids
- Antibiotics and oral steroids for exacerbations
- Oxygen in later stages