The Cardiac Cycle

Original Author: Brendan Donnelly
Last Updated: 22nd December 2017
Revisions: 11

At rest the heart pumps around 5L of blood around the body every minute, but this can increase massively during exercise. In order to achieve this high output efficiently the heart works through a carefully controlled sequence with every heart beat – this sequence of events is known as the cardiac cycle.

Pressures Within the Heart

Table 1 – Pressures observed within cardiac chambers during systole and diastole
Heart region Pressure (mmHg)
Right atrium 0-4
Right ventricle 25 systolic; 4 diastolic
Pulmonary artery 25 systolic; 10 diastolic
Left atrium 8-10
Left ventricle 120 systolic; 10 diastolic
Aorta 120 systolic; 80 diastolic

The above table shows the range of pressures present throughout the heart during the cardiac cycle. Knowing these values often help to understand the progression between different stages of the cycle, for example the pulmonary artery has a systolic pressure of 25mmHg, so the right ventricle must be able to match this force in order to successfully eject blood.

The Cardiac Cycle

The stages of the cardiac cycle can be roughly divided into the four stages:

  • Filling phase – the ventricles fill during diastole and atrial systole
  • Isovolumetric contraction – the ventricles contract, building up pressure ready to pump blood into the aorta/pulmonary trunk
  • Outflow phase – the ventricles continue to contract, pushing blood into the aorta and the pulmonary trunk. Also known as systole
  • Isovolumetric relaxation – the ventricles relax, ready to re-fill with blood in the next filling phase

In this article we will discuss each of the phases in more detail; describing the changes in pressure and the actions of the heart valves in the cardiac cycle.

You can read more on the anatomy of the cardiac valves here.

Filling Phase

The ventricles are filled with blood in two stages – diastole (heart relaxation) and atrial systole (contraction of the atria).

In diastole both the atria and the ventricles are relaxed. Blood flows from the vena cava and pulmonary veins into the right and left atria respectively, before flowing directly into the ventricles. The ventricles fill with blood at a steadily decreasing rate, until the pressure in the ventricles is equal to that in the veins.

At the end of diastole the atria contract, squirting a small amount of extra blood into the ventricles. This increases the pressure in the ventricles so that it is now higher than that in the atria, causing the atrioventricular valves (mitral/tricuspid) to close.

Isovolumetric Contraction

As contraction begins both sets of valves are closed, meaning that no blood can escape from the ventricles. The start of systole therefore massively increases the pressure within the ventricles, ready to eject blood into the aorta and pulmonary trunk. The stage of isovolumetric contraction lasts for approximately 50ms while the pressure builds.

Outflow Phase

Once the pressure in the ventricles exceeds the pressure in the aorta/pulmonary trunk the outflow valves (aortic/pulmonary) open. Blood is pumped from the heart into the great arteries.

At the end of systole, around 330ms later, the ventricles begin to relax and this decrease in pressure compared to the aorta causes the valves to close. As well as this, blood begins to flow backwards through the outflow valves, which also contributes to the closure of the valves.

Isovolumetric Relaxation

At the end of the outflow phase both sets of valves are closed once again. The ventricles begin to relax, reducing the pressure in the ventricles so that the atrioventricular valves open. The ventricles then begin to fill with blood and the cycle begins once again.

cardiac cycle better

Fig 1 – Pressure changes and important events within the cardiac cycle, a single cycle is shown.

Clinical Relevance – Cardiac Auscultation

The carefully co-ordinated sequence of events described in this article mean that, in the healthy heart, blood flows smoothly and so cannot be heard on auscultation. What can be heard when listening to the heart are two sounds, sometimes described as a “lub” and a “dub”. These sounds are caused by the closure of valves in the cardiac cycle:

  • S1 (the “lub”): occurs at the end of the filling phase when the atrioventricular valves snap shut
  • S2 (the “dub”): occurs at the end of the outflow phase when the outflow valves snap shut

Damage to the heart valves can cause them to become narrowed (stenosis) or leaky (regurgitation). Either of these conditions can lead to turbulent blood flow which is heard as a humming sound on auscultation of the heart. These sounds are known as heart murmurs.

cardiac auscultation

Fig 2 – Surface anatomy of the best locations to auscultate the four heart valves.

Clinical Relevance – Additional Heart Sounds

Occasionally within clinical practice additional heart sounds can be heard, these are termed S3 and S4 and can be heard in the following situations:

  • S3 : this sound can sometimes be heard early in diastole (following S2), in young people or athletes it is normal, however in older patients it often indicates congestive heart failure. It is caused by deceleration of blood moving from the left atrium to the left ventricle.
  • S4 : this sound can sometimes be heard during atrial contraction (late diastole, immediately before S1) and is associated with reduced ventricular compliance (“stiff” ventricles) or left ventricular hypertrophy.


Question 1 / 6
Thinking of average pressure differences, which of the following statements is false?


Question 2 / 6
During which phase does most ventricular filling occur?


Question 3 / 6
Which is the correct sequence of events in the cardiac cycle? Filling phase...


Question 4 / 6
During which phase will the ventricles experiences the steepest rise in pressure?


Question 5 / 6
What does the second heart sound (S2) correlate to?


Question 6 / 6
Which of these cannot be a murmur?


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